Preheat a large skillet to medium heat with a drizzle of cooking oil, the squash, zucchini, salt, onion and garlic powders, and pepper(s).
Sauté the veggie mixture for about ten minutes, stirring as you go, until the veggies are soft and most of the liquid has evaporated. Transfer the mixture to a large mixing bowl.
Let the squash mixture cool for 5-10 minutes. Meanwhile, prepare a baking dish with cooking spray.
When the squash mixture has cooled, add the sour cream, mayo, and cheese to the squash. Stir to combine and taste; add more salt and pepper until the mixture is very flavorful.
Transfer the mixture to the casserole dish and top it with the crushed crackers. (this is the point you will stop if making the casserole in advance)
When ready to eat, bake the casserole at 375F for 30 minutes or until bubbly at the edges and hot all the way through.
Let the casserole rest for 5-10 minutes before serving with your favorite meal. YES.